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Madeleine L H Campbell Synonym (s): Clenbuterol Uses Administration Precautions Adverse Reactions Introduction Name Clenbuterol hydrochloride. Class of drug Sympathomimetic bronchodilator. Uses This article is available in full to registered subscribers. The drug is normally administered to horses orally as a syrup formulation. Once absorbed into the systemic circulation, clenbuterol has the potential to cause many side effects, including a repartitioning effect and major alterations in cardiac and skeletal muscle function. Ventipulmin Syrup (clenbuterol hydrochloride) is antagonized by beta-adrenergic blocking agents. For use in horses not intended for food. Each ml contains: Clenbuterol HCl 72. Contraindications: Ventipulmin Syrup antagonizes the effects of prostaglandin F2 alpha and oxytocin. Ventipulmin Syrup should not be used in pregnant mares near term. A second group of six horses received clenbuterol according to the incremental dosing protocol outlined on the manufacturer’s label: 0. 8 mcg/kg twice daily for 3 days, 1. 6 mcg/kg twice daily for 3 days, 2. 4 mcg/kg twice daily for 3 days and 3. 2 mcg/kg twice daily for the remainder of the 30-day dosing protocol. Dosage & Administration Remove safety cap and seal; replace with enclosed dispensing cap. Connect syringe (without needle) to dispensing tip and draw out appropriate volume of Ventipulmin¬ Syrup (clenbuterol hydrochloride). Administer to horse orally twice a day (b. Initial dose is 0. 5 mL/100 lbs body weight (0. 8 mcg/kg) twice daily. Clenbuterol is an agonist at the beta-2 adrenergic receptor, which is a member of the 7-transmembrane receptor superfamily and activates adenylate cyclase, the end result of which is a relaxation of smooth bronchial muscle and a decrease in airway obstruction (Johnson, 1998). From: Reference Module in Biomedical Sciences, 2015 Related terms:. CLENBUTEROL HYDROCHLORIDE SUMMARY REPORT (1) 1. Clenbuterol is a direct-acting 2-sympathomimetic agent. It is manufactured as a 50:50 racemic mixture. Most of the pharmacological activity is associated with the Laevo form. Clenbuterol is used as a bronchodilator for horses and non-lactating cattle. Greater determination Why do people use clenbuterol? Clenbuterol’s initial use was as an asthma drug. However, bodybuilders, performance athletes, and those wanting to lose weight are now using
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