A, androstenedione; BMP, bone morphogenetic protein; E, estradiol; FGF, fibroblast growth factor; FSH, follicle-stimulating hormone; GDF, growth differentiation factor; HGF, hepatocyte growth factor; IGF, insulin-like growth factors; KGF, keratinocyte-derived growth factor; KL, kit ligand; LH, luteinizing hormone; TGF, transforming growth factor. Although most studies of ovarian steroidogenesis focus on the production of biologically active hormones, ovarian steroidogenic cells secrete metabolites of these hormones that lack the classical hormone activity. For example, the human corpus luteum secretes large quantities of 5α-dihydroprogesterone, a molecule that has no progestational activity, but can modulate neuronal γ-aminobutyric acid (GABA) receptors. Steroid biosynthesis and metabolism involve multiple cytochrome P450 proteins that require P450 oxidoreductase (POR) in the reaction as shown in Figure 2 (Lu et al. Related terms: Leydig Cell Mitochondrion Progesterone Steroid Luteinizing Hormone Cortisol Steroids Nested Gene Testosterone, dianabol 25mg capsules.
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