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The action of the beta-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles. The Biochemical journal 261, 965–971, doi: 10. 20231 Abstract Aims: This study investigates the effects of 138-355, an active-metabolite of TT-138 and beta(3)-adrenoceptor agonist, on relaxation of the human detrusor in vitro. Methods: Tissues were mounted in 5 or 10 ml organ baths containing Krebs solution, which was gassed with 95% O(2) and 5% CO(2). Clenbuterol is a beta agonist. In some parts of the world, it is used to treat breathing difficulties caused by conditions such as asthma or chronic obstructive pulmonary disease (COPD). In the United States, however, clenbuterol is not approved for this purpose. Clenbuterol is a beta2-adrenoceptor agonist marketed as an asthma reliever but is not approved for human use in most countries due to concerns of adverse cardiac effects. Clenbuterol is an agonist at the beta-2 adrenergic receptor, which is a member of the 7-transmembrane receptor superfamily and activates adenylate cyclase, the end result of which is a relaxation of smooth bronchial muscle and a decrease in airway obstruction (Johnson, 1998). From: Reference Module in Biomedical Sciences, 2015 View all Topics. Beta-agonists are used for growth promotion in food animals, increasing lean muscle mass. In humans, clenbuterol and salbutamol are used as bronchodilators by asthma sufferers and as performance-enhancing drugs by athletes. Human side effects include increased heart rate and blood pressure, anxiety, palpitation, and skeletal muscle tremors https://hs.entecreativo.com/activity/p/28340/
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